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An. bras. dermatol ; 86(1): 31-36, jan.-fev. 2011. tab
Article in Portuguese | LILACS | ID: lil-578303

ABSTRACT

FUNDAMENTOS: prurido é o sintoma mais freqüente nos pacientes nefropatas em hemodiálise. Parâmetros laboratoriais anormais têm sido encontrados, com dados conflitantes. OBJETIVO: relacionar a prevalência de prurido com alterações no metabolismo mineral de pacientes em hemodiálise. MÉTODOS: estudo caso-controle. Avaliados 105 pacientes, sendo os pacientes com prurido os casos, preencheram o questionário do protocolo de pesquisa e a escala análoga visual, os dados laboratoriais foram coletados dos prontuários eletrônicos. RESULTADOS: a média de idade foi de 51,9 anos, 59 por cento dos pacientes eram homens e 43 por cento dos pacientes tinham prurido. Xerodermia ocorreu em 45 por cento dos pacientes. Níveis elevados de Ca foram demonstrados em 55 por cento dos pacientes e 47 por cento tinham prurido. Quanto ao fósforo 60 por cento tinham valores elevados e 43 por cento tinham prurido. A relação Ca/P foi normal em todos. O paratormônio mostrou-se elevado em 95 por cento dos pacientes, todos referindo prurido. CONCLUSÃO: houve associação estatisticamente significativa entre o grupo de pacientes com prurido e xerodermia. Os níveis séricos de Cálcio, Fósforo, relação Ca/P, PTHi e o tamanho do dialisador não apresentaram associação estatisticamente significativa com o prurido. Logo, encontramos relação importante entre xerodermia e prurido, sem relação com os parâmetros laboratoriais avaliados.


BACKGROUND: Uremic pruritus is the most frequent symptom in long-term hemodialysis patients. Abnormal laboratory parameters have been found with conflicting data. OBJECTIVE: To correlate the prevalence of pruritus with alterations in mineral metabolism in hemodialysis patients. METHODS: This was a case-control study. A hundred and five patients on maintenance hemodialysis were evaluated: a group of patients with pruritus and a control group. They answered a research protocol questionnaire; laboratory data were collected from medical records and the patients with pruritus filled out a visual analogue scale (VAS) to measure pruritus level. RESULTS: The mean age was 51.9 years; 59 percent of the patients were men and 43 percent of the patients had pruritus. Xeroderma occurred in 45 percent of the patients. High levels of calcium were demonstrated in 55 percent of the patients and 47 percent had pruritus. 60 percent of the patients had high phosphorus levels and 43 percent had pruritus. The Ca/P ratio was normal for all the patients. Parathyroid hormone was high in 95 percent of the patients, all of them referring pruritus. CONCLUSION: There was a statistically significant association between the group of patients with pruritus and xeroderma. Serum calcium and phosphorus levels, Ca/P ratio, PTHi and size of the dialyzer did not show a statistically significant association with pruritus. Therefore, we found an important relationship between xeroderma and pruritus, with no relation with the assessed laboratory parameters.


Subject(s)
Female , Humans , Male , Middle Aged , Minerals/metabolism , Pruritus/epidemiology , Renal Dialysis/adverse effects , Brazil/epidemiology , Case-Control Studies , Chi-Square Distribution , Calcium/metabolism , Kidney Failure, Chronic/therapy , Prevalence , Phosphorus/metabolism , Pruritus/metabolism , Sex Distribution , Time Factors , Urea/metabolism
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